Radiesse is a long-lasting injectable, providing positive effects for the body longer than most other injectables on the market. The results of a Radiesse treatment usually last for at least a year, and depending on factors such as metabolism, a treatment has even been known to stay for up to three years. It may be necessary to get minor touchups during this period.
As Radiesse is a temporary dermal filler, the calcium hydroxylapatite spheres it contains will at some point disintegrate into their component calcium and phosphate elements. Your system will harmlessly absorb these. The water-based gel that the spheres come in will also dissipate harmlessly.